Running toward a world where every girl with Rett Syndrome can walk, talk, and live a life of her own.
For families affected by Rett Syndrome, every day is a marathon. It's a journey of endurance, resilience, and unwavering hope. We are running this race not just for the miles, but for the milestones.
The Hope Marathon was born from a simple dream: that our little girl—and thousands like her—will someday have the independence she deserves. Every step we take in Prosper is a step closer to a cure.
Rett Syndrome is a rare genetic neurological disorder that leads to severe impairments, affecting nearly every aspect of a child's life: their ability to speak, walk, eat, and even breathe easily.
It primarily affects females (about 1 in 10,000 births). Children often develop normally for the first 6-18 months before a period of regression begins.
Despite the challenges, these children are known for their bright eyes and incredible spirits. They are "locked in," waiting for the science that will set them free.
We are living in a historic moment. For the first time, a cure for Rett Syndrome isn't just a dream—it's a scientific objective.
Companies like Taysha Gene Therapies and Neurogene are pioneering treatments that target the root cause of Rett Syndrome: the MECP2 gene. Clinical trials are already underway, showing the potential to restore function and change lives forever.
Funds raised through the Hope Marathon directly support organizations like Rettsyndrome.org and the Rett Syndrome Research Trust, ensuring that the best scientists in the world have the resources they need to cross the finish line.
Whether you're a competitive runner or a casual walker, your participation makes a difference. Join us in Prosper, TX in the Spring of 2026.
More details on the exact date and course coming soon.